Yes. With the exception of the image previewer, every aspect of Mayan EDMS is file format agnostic. This means that you can upload video and music files and still use tagging, indexing, workflows, and digital signatures on those files.
A common use case is for organizations to upload video and audio recordings, such as depositions, hearings, and council meeting audio recording along side the written documents of the meeting. This way all documents can be indexed with the same information like metadata and tags.